Each 'bird's nest' in the image a single worm's trajectory through the shape space defined by three eigenworms (colour indicates position in the fourth dimension).


Google Scholar Profile

A Javer, M Currie, C Lee, J Hokanson, K Li, CN Martineau, E Yemini, LJ Grundy, C Li, Q Ch’ng, WR Schafer, EAA Nollen, R Kerr, AEX Brown
An open-source platform for analyzing and sharing worm-behavior data
Nature Methods 15:645 (2018)
[Abstract] [pdf]

A Javer, L Ripoll-Sanchez, AEX Brown
Powerful and interpretable behavioural features for quantitative phenotyping of C. elegans
Phil Trans R Soc B 373:20170375 (2018)
[Abstract] [pdf]
Special issue: [Intro] [Contents]

YL Chew, LJ Grundy, AEX Brown, I Beets, WR Schafer
Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in C. elegans via the receptor SEB-3
Phil Trans R Soc B 373:20170375 (2018)
[Abstract] [pdf]
Special issue: [Intro] [Contents]

AEX Brown, BL de Bivort
Ethology as a physical science
Nature Physics doi:10.1038/s41567-018-0093-0 (2018)
[Abstract] [pdf]

K Li, A Javer, EE Keaveny, AEX Brown
Recurrent Neural Networks with Interpretable Cells Predict and Classify Worm Behaviour
NIPS Workshop Paper (2017)
[Best paper award!] [pdf]

EE Keaveny, AEX Brown
Predicting path from undulations for C. elegans using linear and nonlinear resistive force theory
Physical Biology 14:025001 (2017)
[Abstract] [pdf]
[Code on GitHub]

A Gomez-Marin, GJ Stephens, AEX Brown
Hierarchical compression of C. elegans locomotion reveals phenotypic differences in the organisation of behaviour
Journal of the Royal Society Interface 13:20160466 (2016)
[Abstract] [pdf]
[Code on GitHub]

B Gyenes, AEX Brown
Deriving shape-based features for C. elegans locomotion using dimensionality reduction methods
Frontiers in Behavioral Neuroscience 10:159 (2016)
[Abstract] [pdf]

RF Schwarz, R Branicky, LJ Grundy, WR Schafer, AEX Brown
Changes in postural syntax characterize sensory modulation and natural variation of C. elegans locomotion
PLOS Computational Biology 11:e1004322 (2015)
[Abstract] [pdf]
[Code on GitHub]

Y Koren, R Sznitman, PE Arratia, C Carls, P Krajacic, AEX Brown, J Sznitman
Model-Independent Phenotyping of C. elegans Locomotion Using Scale-Invariant Feature Transform
PLOS ONE 10:e0122326 (2015)
[Abstract] [pdf]

EI Yemini, AEX Brown
Tracking single C. elegans using a USB microscope on a motorised stage
Methods in Molecular Biology 1327:181 (2015)
[Abstract] [pdf]

E Yemini, T Jucikas, L Grundy, AEX Brown*, WR Schafer*
A database of C. elegans behavioral phenotypes
Nature Methods 10:877–879 (2013)
[Abstract] [pdf]
Coverage: [Open Helix blog]

AEX Brown, E Yemini, L Grundy, T Jucikas, WR Schafer
A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion
Proc. Nat. Acad. Sci. USA 110:791-796 (2013)
[Abstract] [pdf]
Coverage: [F1000 (rated exceptional)] [Nature Methods highlight]
[Code on GitHub]

CA Russell, JM Fonville, AEX Brown, DF Burke, DL Smith, SL James, S Herfst, S van Boheemen, M Linster, EJ Schrauwen, L Katzelnick, A Mosterín, T Kuiken, E Maher, G Neumann, ADME Osterhaus, Y Kawaoka, RAM Fouchier, DJ Smith
The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host
Science 336:1541-1547 (2012)
[Abstract] [pdf]
Coverage: [Science News & Analysis] [Wired]

F Rehfeldt, AEX Brown, M Raab, S Cai, AL Zajac, A Zemel, DE Discher
Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells
Integrative Biology 4:422-430 (2012)
[Abstract] [pdf]

AEX Brown, WR Schafer
Unrestrained worms bridled by the light
Nature Methods 8:129-30 (2011)
[Abstract] [pdf]

A Zhmurov, AEX Brown, RI Litvinov, RI Dima, JW Weisel, V Barsegov
Mechanism of fibrin(ogen) forced unfolding
Structure 19:1615-24 (2011)
[Abstract] [pdf]

PK Purohit, RI Litvinov, AEX Brown, DE Discher, JW Weisel
Protein unfolding accounts for the unusual mechanical behavior of fibrin networks
Acta Biomaterialia 7:2374-2383 (2011)
[Abstract] [pdf]

A Zemel*, F Rehfeldt*, AEX Brown, DE Discher, SA Safran
Optimal matrix rigidity for stress-fiber polarization in stem cells
Nature Physics 6:468-473 (2010)
*contributed equally
[Abstract] [pdf]

K Rajagopal, A Mahmud, DA Christian, JD Pajerowski, AEX Brown, SM Loverde, DE Discher
Curvature-Coupled Hydration of Semicrystalline Polymer Amphiphiles Yields flexible Worm Micelles but Favors Rigid Vesicles: Polycaprolactone-Based Block Copolymers
Macromolecules 43:9736–9746 (2010)
[Abstract] [pdf]

CC Krieger, N Bhasin, M Tewari, AEX Brown, D Safer, HL Sweeney, DE Discher
Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: Mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics
Cytoskeleton 67:796-807 (2010)
[Abstract] [pdf]

A Buxboim, K Rajagopal, AEX Brown, DE Discher
How deeply cells feel: methods for thin gels
Journal of Physics: Condensed Matter 22:194116 (2010)
[Abstract] [pdf]

A Zemel, F Rehfeldt, AEX Brown, DE Discher, SA Safran
Cell shape, spreading symmetry and the polarization of stress-fibers in cells
Journal of Physics: Condensed Matter 22:194110 (2010)
[Abstract] [pdf]

AEX Brown and DE Discher
Conformational Changes in Cell and Matrix Physics
Current Biology 19:R781-R789 (2009)
[Abstract] [pdf]

AEX Brown, RI Litvinov, DE Discher, PK Purohit, JW Weisel
Multiscale Mechanics of Fibrin Polymer: Gel Stretching with Protein Unfolding and Loss of Water
Science 325:741-744 (2009)
[Abstract] [pdf]
Coverage: [Eurekalert] [NPR]

AEX Brown*, A Hategan*, D Safer, YE Goldman, DE Discher
Cross-correlated TIRF/AFM reveals Asymmetry in Self-assembled Synthetic Myosin Filaments
Biophysical Journal 96:1952-1960. (2009)
*contributed equally
[arXiv] [Abstract] [pdf]

IM Kulic, AEX Brown, H Kim, C Kural, B Blehm, PR Selvin, PC Nelson, VI Gelfand
The Role of Microtubule Movement in Bidirectional Organelle Transport
Proc. Nat. Acad. Sci. 105:10011-10016 (2008)
[Abstract] [arXiv] [pdf]

AEX Brown, RI Litvinov, DE Discher, JW Weisel
Forced Unfolding of Coiled-coils in Fibrinogen by Single Molecule AFM
Biophysical Journal - Letters. 92:L39-L41. (2007)
[Abstract] [PubMed Central] [pdf]
Coverage: [Eurekalert]

A Brown, I Skanes, MR Morrow
Pressure Induced Ordering in mixed-lipid bilayers
Physical Review E 69:011913. (2004)
[Abstract] [pdf]